The federal government shut down Wednesday after Democrats refused to drop demands to preserve health care subsidies, clashing with President Trump and Republicans who dismissed the issue.

The White House warned of mass layoffs beyond the usual furloughs, with 750,000 federal workers affected and many offices closing, as Trump pushes ahead with his agenda while cutting Democratic programs.

No new negotiations are planned after failed talks, and a GOP funding bill without subsidies fell short in the Senate despite some Democratic support, the Associated Press has reported.

This marks Trump’s third shutdown as president and highlights the deep partisan standoff over budget priorities.